منابع مشابه
An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.
Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all three markers (triple negative or basal-like). While targeted therapies for ER+/PR+ and HER2+ tumors have revolutionized patient treatment and increased lifespan, an urgent need exists for identifyi...
متن کاملTriple sugar screen breath hydrogen test for sugar intolerance in children with functional abdominal symptoms.
BACKGROUND Sugar intolerance and functional gastrointestinal disorders are both common in school age children. Both may present with similar complaints such as abdominal pain, diarrhea and bloating. Lactose, fructose and sucrose hydrogen breath tests are widely used to detect sugar malabsorption. AIM To determine the proportion of children with symptoms of functional gastrointestinal disorder...
متن کاملHigh-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) represents an aggressive subtype, for which radiation and chemotherapy are the only options. Here we describe the identification of disulfiram, an FDA-approved drug used to treat alcoholism, as well as the related compound thiram, as the most potent growth inhibitors following high-throughput screens of 3185 compounds against multiple TNBC cell lines. The av...
متن کامل[Amniotic chromosomal analysis in pregnant women identified by triple-marker testing as screen positive.].
BACKGROUND Maternal serum triple marker screening (alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol) can detect 60-70% of Down syndrome and 60% of Edwards syndrome. Previous studies have reported that positive serum screening is related to other fetal chromosomal abnormalities, pregnancy complications, and adverse outcomes. We determined the incidence and karyotype of c...
متن کاملEvaluation of Dried Urine Spot Method to Screen Cotinine among Tobacco Dependents: An Exploratory Study
BACKGROUND AND OBJECTIVES Assessment of cotinine, a metabolite of nicotine in body fluids, is an important approach for validating the self-report among tobacco users. Adaptation of assays on dried urine spots (DUSs) has advantages of ease of collection, transportation, minimal invasiveness, and requirement of small volume. The aim of the present study was to develop an efficient method for tes...
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ژورنال
عنوان ژورنال: American Journal of Preventive Medicine
سال: 2013
ISSN: 0749-3797
DOI: 10.1016/j.amepre.2013.07.007